The link didnt open for me, I did look up both powdery and downy color wrong. Can grapes get apple ceder rust ? Redish brown group of spots raised up on back side of leaf
That might be some kind of bug, that laid eggs in the raised up area. If you have a microscope, you may be able to cut the bump open and look at it, possibly seeing an egg or larvae. If this is what you have, and only one leaf has it, just burn the leaf and count your blessings.