it's early and i'm in a bit of a rambly mood so i'm just going to write what comes to mind...
i like having larger spaces to work with. that is much more flexible than a bunch of small spaces. we are consolidating gardens here as i get time for them. i hate wasting space on pathways. you can use the rows between plants as pathways well enough. if it gets too wet and muddy that is usually a good sign to stay out of a garden anyways if you can help it (to avoid compacting the soil). the following seasons you can change your layouts without having to deal with moving a hardscape pathway.
plus every edge is maintenance one way or another. if you don't do them well it ends up costing you work later. but there is also no free lunch.
each season i try to plan a few projects for the start and the end of the season where it is cooler and i'm more able to work harder (heat stroke or heat exhaustion is no fun, make sure you have enough water in your system

). i may not get them done, but at least i can make progress.
it may not always work perfectly in all gardens and crops, that is why diversity in plantings is important. failures can teach a lot more than success. etc. etc. if that is true i must also be a genius... haha...
grow things you like to eat, and then try a few new crops here or there too, but not too much because it can be rather sad to see a large space essentially wasted because nobody will eat them.
don't be afraid to take things out that aren't working as soon as you decide you have a better crop to put in. peas/beans are great crops for us. buckwheat is a great cover crop if you are not using a space for a month. winter cover crops are nice and they can keep weeds down and help hold nutrients for the coming season and also add more value (free energy from the sun, free worm food, etc.). yep, they can cost a little to put in and need turning under in the spring, but that's better than having bare dirt all winter.